NDLI: Age-dependent alteration in muscle regeneration: the critical role of tissue niche

Content Provider	Springer Nature Link
Author	Barberi, Laura Scicchita, Bianca Maria De Rossi, Manuela Bigot, Anne Duguez, Stephanie Wielgosik, Aurore Stewart, Claire McPhee, Jamie Conte, Maria Narici, Marco Franceschi, Claudio Mouly, Vincent Butler Browne, Gillian Musarò, Antonio
Copyright Year	2013
Abstract	Although adult skeletal muscle is composed of fully differentiated fibers, it retains the capacity to regenerate in response to injury and to modify its contractile and metabolic properties in response to changing demands. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic precursor cells that reside between the basal lamina and plasmalemma and that are rapidly activated in response to appropriate stimuli. However, in pathologic conditions or during aging, the complete regenerative program can be precluded by fibrotic tissue formation and resulting in functional impairment of the skeletal muscle. Our study, along with other studies, demonstrated that although the regenerative program can also be impaired by the limited proliferative capacity of satellite cells, this limit is not reached during normal aging, and it is more likely that the restricted muscle repair program in aging is presumably due to missing signals that usually render the damaged muscle a permissive environment for regenerative activity.
Starting Page	273
Ending Page	292
Page Count	20
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	14
Issue Number	3
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sarcopenia Muscle regeneration Satellite cells Tissue niche Growth factors Stem cells Cell Biology Geriatrics/Gerontology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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