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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sharma, Deepak Sethi, Pallavi Hussain, Ezaj Singh, Rameshwar |
| Copyright Year | 2008 |
| Abstract | This study investigated the effect of curcumin on aluminium-induced alterations in ageing-related parameters: lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST), protein kinase C (PKC), Na+, K+-adenosine triphosphatase (Na+, K+-ATPase) and acetylcholinesterase (AChE) in the cerebral cortex and hippocampus of the brain of 10- and 24-month-old rats. Measurements taken from aluminium-fed rats were compared with those from rats in which curcumin and aluminium were co-administered. In aluminium-treated rats the levels of lipid peroxidation, PKC and AChE were enhanced while the activities of SOD, GPx, GST and Na+, K+-ATPase were significantly decreased in both the brain regions of both age-groups. In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na+, K+-ATPase were significantly enhanced in the two brain regions studied indicating curcumin’s protective effects against aluminium toxicity. Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na+, K+ ATPase, PKC and AChE. Therefore, it is suggested that curcumin counters aluminium-induced enhancement in ageing-related processes. |
| Starting Page | 489 |
| Ending Page | 502 |
| Page Count | 14 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 10 |
| Issue Number | 4 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2008-11-20 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-ageing effects Antioxidant enzymes Curcumin Na+ K+-ATPase Protein kinase C Aluminium-induced neurotoxicity Glutathione-s-transferase Superoxide dismutase Glutathione peroxidase Lipid peroxidation Oxidative stress Developmental Biology Geriatrics/Gerontology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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