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Male Drosophila melanogaster flies exposed to hypergravity at young age are protected against a non-lethal heat shock at middle age but not against behavioral impairments due to this shock

Dietary restriction in aged mice can partially restore impaired metabolism of apolipoprotein A-IV and C-III

Acknowledgments

Biogerontology : Volume 5, Issue 5, October 2004

Biogerontology : Volume 5, Issue 4, August 2004

Biogerontology : Volume 5, Issue 3, June 2004

Biogerontology : Volume 5, Issue 2, April 2004

Biogerontology : Volume 5, Issue 1, February 2004

Biogerontology : Volume 4

Biogerontology : Volume 3

Biogerontology : Volume 2

Biogerontology : Volume 1

Dietary restriction in aged mice can partially restore impaired metabolism of apolipoprotein A-IV and C-III

Content Provider	Springer Nature Link
Author	Araki, Sachiko Goto, Sataro
Copyright Year	2004
Abstract	Dietary restriction (DR) is only one well-established non-genetic experimental means to retard aging in various species of animals. Here we demonstrated that DR in mice for 3months initiated late in life, at the age of 22months, partially restores age-related decline of serum apolipoprotein A-IV (apo A-IV) level and the gene expression found in the liver of ad libitum fed young animals as revealed by fasting. In contrast, increase in gene expression of apo C-III by fasting was higher in the aged than that in the young, but it was reduced to the level of young animals in DR counterparts of the aged. In view of the implication that apo A-IV and C-III are involved in the activation and inhibition of lipoprotein lipase, respectively, the adult onset DR can conceivably upregulate the activity of this enzyme that is likely reduced in aged animals and thus improve the lipid metabolism. The present findings suggest that DR initiated even relatively late in life may reduce risk of age-related diseases associated with impaired lipid metabolism.
Starting Page	445
Ending Page	450
Page Count	6
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	5
Issue Number	6
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	aging apolipoprotein A-IV apolipoprotein C-III dietary restriction fasting liver Geriatrics/Gerontology Proteomics Cell Biology Developmental Biology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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Contents Volume 2

Dietary restriction in aged mice can partially restore impaired metabolism of apolipoprotein A-IV and C-III

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Contents Volume 2

Dietary restriction in aged mice can partially restore impaired metabolism of apolipoprotein A-IV and C-III