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| Content Provider | Springer Nature Link |
|---|---|
| Author | Villalba, José Manuel López Domínguez, José Alberto Chen, Yana Khraiwesh, Husam González Reyes, José Antonio Río, Lucía Fernández Gutiérrez Casado, Elena Río, Mercedes Calvo Rubio, Miguel Ariza, Julia Cabo, Rafael López Lluch, Guillermo Navas, Plácido Hagopian, Kevork Burón, María Isabel Ramsey, Jon Jay |
| Copyright Year | 2015 |
| Abstract | The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR) without malnutrition extends lifespan in many model organisms, which may be related to alterations in membrane phospholipids fatty acids. During the last few years our research focused on studying how altering the predominant fat source affects the outcome of CR in mice. We have established four dietary groups: one control group fed 95 % of a pre-determined ad libitum intake (in order to prevent obesity), and three CR groups fed 40 % less than ad libitum intake. Lipid source for the control and one of the CR groups was soybean oil (high in n-6 PUFA) whereas the two remaining CR groups were fed diets containing fish oil (high in n-3 PUFA), or lard (high in saturated and monounsaturated fatty acids). Dietary intervention periods ranged from 1 to 18 months. We performed a longitudinal lifespan study and a cross-sectional study set up to evaluate several mitochondrial parameters which included fatty acid composition, H+ leak, activities of electron transport chain enzymes, ROS generation, lipid peroxidation, mitochondrial ultrastructure, and mitochondrial apoptotic signaling in liver and skeletal muscle. These approaches applied to different cohorts of mice have independently indicated that lard as a fat source often maximizes the effects of 40 % CR on mice. These effects could be due to significant increases of monounsaturated fatty acids levels, in accordance with the Membrane Theory of Aging. |
| Starting Page | 655 |
| Ending Page | 670 |
| Page Count | 16 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 16 |
| Issue Number | 5 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-04-10 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Apoptotic signaling Calorie restriction Dietary fat Lifespan Mitochondria Proton leak Cell Biology Geriatrics/Gerontology Developmental Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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