NDLI: Mild heat treatments induce long-term changes in metabolites associated with energy metabolism in Drosophila melanogaster

Content Provider	Springer Nature Link
Author	Sarup, Pernille Petersen, Simon Metz Mariendal Nielsen, Niels Chr. Loeschcke, Volker Malmendal, Anders
Copyright Year	2016
Abstract	Heat-induced hormesis, the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. Yet little is known about the mechanisms underlying this effect. We used nuclear magnetic resonance spectroscopy to investigate the long-term effects of repeated mild heat treatments on the metabolome of male Drosophila melanogaster. 10 days after the heat treatment, metabolic aging appears to be slowed down, and a treatment response with 40 % higher levels of alanine and lactate and lower levels of aspartate and glutamate were measured. All treatment effects had disappeared 16 days later. Metabolic reprogramming has been associated with the life extending effects of dietary restriction. The metabolite changes induced by the hormetic treatment suggest that the positive effects might not be limited to the repair pathways induced, but that there also is a change in energy metabolism. A possible direct link between changes in energy metabolism and heat induced increase in Hsp70 expression is discussed.
Starting Page	873
Ending Page	882
Page Count	10
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	17
Issue Number	5-6
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-08-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Energy metabolism NMR Heat stress Hsp70 Hormesis Longevity Metabolomics Cell Biology Geriatrics/Gerontology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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