NDLI: Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

Content Provider	Springer Nature Link
Author	Montesanto, Alberto Crocco, Paolina Tallaro, Federica Pisani, Francesca Mazzei, Bru Mari, Vincenzo Corsonello, Andrea Lattanzio, Fabrizia Passari, Giuseppe Rose, Giuseppina
Copyright Year	2013
Abstract	Nitric oxide (NO) triggers multiple signal transduction pathways and contributes to the control of numerous cellular functions. Previous studies have shown in model organisms that the alteration of NO production has important effects on aging and lifespan. We studied in a large sample (763 subjects, age range 19–107 years) the variability of the three human genes (NOS1, -2, -3) coding for the three isoforms of the NADPH-dependent enzymes named NO synthases (NOS) which are responsible of NO synthesis. We have then verified if the variability of these genes is associated with longevity, and with a number of geriatric parameters. We found that gene variation of NOS1 and NOS2 was associated with longevity. In addition NOS1 rs1879417 was also found to be associated with a lower cognitive performance, while NOS2 rs2297518 polymorphism showed to be associated with physical performance. Moreover, SNPs in the NOS1 and NOS3 genes were respectively associated with the presence of depression symptoms and disability, two of the main factors affecting quality of life in older individuals. On the whole, our study shows that genetic variability of NOS genes has an effect on common age related phenotypes and longevity in humans as well as previously reported for model organisms.
Starting Page	177
Ending Page	186
Page Count	10
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	14
Issue Number	2
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-04-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NOS Longevity Aging Nitric oxide Polymorphisms Cell Biology Geriatrics/Gerontology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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