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| Content Provider | Springer Nature Link |
|---|---|
| Author | Morrow, Geneviève Pécheur, Marie Tanguay, Robert M. |
| Copyright Year | 2015 |
| Abstract | Aging is characterized by the accumulation of dysfunctional mitochondria. Since these organelles are involved in many important cellular processes, different mechanisms exist to maintain their integrity. Among them is the mitochondrial unfolding protein response, which triggers the expression of a set of proteins aimed at re-establishing mitochondrial homeostasis. The induction of mitochondrial chaperones expression, particularly of Hsp60 and Hsp70, is a hallmark of this pathway. In Drosophila melanogaster, Hsp22 is also up-regulated by mitochondrial stress. This small heat shock protein is one of the members of the family to be localized inside mitochondria. One characteristic of Drosophila Hsp22 is its preferential up-regulation during aging and in oxidative stress conditions. It is a beneficial protein since its over-expression increases lifespan and resistance to stress while its down-regulation is detrimental. This review focuses on Drosophila Hsp22 and its links with the mitochondrial unfolding protein response and the aging process, in addition to highlight the important role of this sHSP in mitochondrial homeostasis. |
| Starting Page | 61 |
| Ending Page | 70 |
| Page Count | 10 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 17 |
| Issue Number | 1 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-07-09 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hsp22 Small heat shock protein (sHSP) Oxidative stress Reactive oxygen species (ROS) Mitochondrial unfolding protein response (UPRMT) Aging Cell Biology Geriatrics/Gerontology Developmental Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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