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| Content Provider | Springer Nature Link |
|---|---|
| Author | Broad, Kevin D. Keverne, Eric B. |
| Copyright Year | 2011 |
| Abstract | Vomeronasal stem cells are generated throughout the life of a mouse and differentiate into neurons that express one vomeronasal type 1 (V1r), one or two vomeronasal type 2 (V2r), or one olfactory receptor. Vomeronasal stem cells can be induced to differentiate into neurons by treatment with lipocalins from mouse urine or by epigenetic modification following treatment with histone deacetylase inhibitors. An important question is, do chemosensory signals, modify the detection capabilities of the vomeronasal organ and affect behaviour. Rearing mice in the presence of urine (and its pheromonal signals) derived from a different mouse strain, affected the behavioural preference for non-kin which were accompanied by changes in vomeronasal receptor expression. Significant changes in the expression of vomeronasal V1r, V2r and olfactory receptors, major urinary proteins, and a number of genes thought to be involved in transcriptional regulation were also observed following urine treatment. These results suggest that modification of a mouse’s urinary environment may exert epigenetic effects on developing vomeronasal neurons, which modify the type of vomeronasal receptors that are expressed. This may provide a mechanism by which environmental changes are able to modify the detection capabilities of the vomeronasal organ to respond optimally to the most likely social environment that a mouse will encounter when mature. |
| Starting Page | 461 |
| Ending Page | 471 |
| Page Count | 11 |
| File Format | |
| ISSN | 00018244 |
| Journal | Behavior Genetics |
| Volume Number | 42 |
| Issue Number | 3 |
| e-ISSN | 15733297 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-12-20 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Vomeronasal receptors Heterozygosity Major urinary proteins Epigenetic Main olfactory receptors Olfactory preference Small nucleolar RNA Health Psychology Public Health/Gesundheitswesen Clinical Psychology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical) |
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