NDLI: Overlaps Between Autism and Language Impairment: Phenomimicry or Shared Etiology?

Content Provider	Springer Nature Link
Author	Bishop, D. V. M.
Copyright Year	2010
Abstract	Traditionally, autistic spectrum disorder (ASD) and specific language impairment (SLI) are regarded as distinct conditions with separate etiologies. Yet these disorders co-occur at above chance levels, suggesting shared etiology. Simulations, however, show that additive pleiotropic genes cannot account for observed rates of language impairment in relatives, which are higher for probands with SLI than for those with ASD + language impairment. An alternative account is in terms of ‘phenomimicry’, i.e., language impairment in comorbid cases may be a consequence of ASD risk factors, and different from that seen in SLI. However, this cannot explain why molecular genetic studies have found a common risk genotype for ASD and SLI. This paper explores whether nonadditive genetic influences could account for both family and molecular findings. A modified simulation involving G × G interactions obtained levels of comorbidity and rates of impairment in relatives more consistent with observed values. The simulations further suggest that the shape of distributions of phenotypic trait scores for different genotypes may provide evidence of whether a gene is involved in epistasis.
Starting Page	618
Ending Page	629
Page Count	12
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	40
Issue Number	5
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2010-07-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Autism Specific language impairment Comorbidity Epistasis Public Health/Gesundheitswesen Health Psychology Clinical Psychology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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Overlaps Between Autism and Language Impairment: Phenomimicry or Shared Etiology?

Overlaps Between Autism and Language Impairment: Phenomimicry or Shared Etiology?

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