NDLI: Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Please wait, while we are loading the content...

Chromosomal Assignment of Quantitative Trait Loci Influencing Modified Hole Board Behavior in Laboratory Mice using Consomic Strains, with Special Reference to Anxiety-related Behavior and Mouse Chromosome 19

Measurement of Segregating Behaviors in Experimental Silver Fox Pedigrees

Sex Combs are Important for Male Mating Success in Drosophila melanogaster

Power Calculations Using Exact Data Simulation: A Useful Tool for Genetic Study Designs

Twin Analysis on Paired Comparison Data

Behavior Genetics : Volume 38, Issue 1, January 2008

Behavior Genetics : Volume 37

Behavior Genetics : Volume 36

Behavior Genetics : Volume 35

Behavior Genetics : Volume 34

Behavior Genetics : Volume 33

Behavior Genetics : Volume 32

Behavior Genetics : Volume 31

Behavior Genetics : Volume 30

Behavior Genetics : Volume 29

Behavior Genetics : Volume 28

Behavior Genetics : Volume 27

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Content Provider	Springer Nature Link
Author	Rommelse, Nanda N. J. Altink, Marieke E. Oosterlaan, Jaap Beem, Leo Buschgens, Cathelijne J. M. Buitelaar, Jan Sergeant, Joseph A.
Copyright Year	2007
Abstract	Attention-Deficit/Hyperactivity Disorder (ADHD) shares a genetic basis with motor coordination problems and probably motor timing problems. In line with this, comparable problems in motor timing should be observed in first degree relatives and might, therefore, form a suitable endophenotypic candidate. This hypothesis was investigated in 238 ADHD-families (545 children) and 147 control-families (271 children). A motor timing task was administered, in which children had to produce a 1,000 ms interval. In addition to this task, two basic motor tasks were administered to examine speed and variability of motor output, when no timing component was required. Results indicated that variability in motor timing is a useful endophenotypic candidate: It was clearly associated with ADHD, it was also present in non-affected siblings, and it correlated within families. Accuracy (under- versus over-production) in motor timing appeared less useful: Even though accuracy was associated with ADHD (probands and affected siblings had a tendency to under-produce the 1,000 ms interval compared to controls), non-affected siblings did not differ from controls and sibling correlations were only marginally significant. Slow and variable motor output without timing component also appears present in ADHD, but not in non-affected siblings, suggesting these deficits not to be related to a familial vulnerability for ADHD. Deficits in motor timing could not be explained by deficits already present in basic motor output without a timing component. This suggests abnormalities in motor timing were predominantly related to deficient motor timing processes and not to general deficient motor functioning. The finding that deficits in motor timing run in ADHD-families suggests this to be a fruitful domain for further exploration in relation to the genetic underpinnings of ADHD.
Starting Page	121
Ending Page	132
Page Count	12
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	38
Issue Number	2
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2007-12-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ADHD Siblings Endophenotype Motor timing Motor speed Motor variability Evolutionary Biology Neurosciences Human Genetics Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Selective Breeding of Reduced Sensorimotor Gating in Wistar Rats

High Heritability for a Composite Index of Children’s Activity Level Measures

Power Calculations Using Exact Data Simulation: A Useful Tool for Genetic Study Designs

Endophenotypes Successfully Lead to Gene Identification: Results from the Collaborative Study on the Genetics of Alcoholism

Behavior Genetics Association 37th Annual Meeting Abstracts

Endophenotype Approach to Developmental Psychopathology: Implications for Autism Research

Perceptual Speed and IQ Are Associated Through Common Genetic Factors

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Similar Documents

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?

Selective Breeding of Reduced Sensorimotor Gating in Wistar Rats

High Heritability for a Composite Index of Children’s Activity Level Measures

Power Calculations Using Exact Data Simulation: A Useful Tool for Genetic Study Designs

Endophenotypes Successfully Lead to Gene Identification: Results from the Collaborative Study on the Genetics of Alcoholism

Behavior Genetics Association 37th Annual Meeting Abstracts

Endophenotype Approach to Developmental Psychopathology: Implications for Autism Research

Perceptual Speed and IQ Are Associated Through Common Genetic Factors

Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?