NDLI: Microarray Analysis of the Effects of a γ-protein Kinase C Null Mutation on Gene Expression in Striatum: A Role for Transthyretin in Mutant Phenotypes

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Microarray Analysis of the Effects of a γ-protein Kinase C Null Mutation on Gene Expression in Striatum: A Role for Transthyretin in Mutant Phenotypes

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Microarray Analysis of the Effects of a γ-protein Kinase C Null Mutation on Gene Expression in Striatum: A Role for Transthyretin in Mutant Phenotypes

Content Provider	Springer Nature Link
Author	Smith, Amy M. Bowers, Barbara J. Radcliffe, Richard A. Wehner, Jeanne M.
Copyright Year	2006
Abstract	A constitutive null mutation of the neural-specific isotype of protein kinase C (γ-PKC) in mice produces alterations in behavioral traits and responses to ethanol suggesting that γ-PKC-mediated phosphorylation is essential for regulation of some behaviors. However, it is possible that some of the effects of γ-PKC gene deletion also may be due to altered gene expression. To examine alterations in gene expression, microarray analyses were performed on striatal tissue from wild types and mutants. A total of 143 genes and ESTs were identified as potential candidates related to differences between null mutants and wild types. Confirmation studies using qRT-PCR indicated that the expression of transthyretin was increased about 8-fold in striatum of naïve mutants compared to wild types. The effect of chronic ethanol treatment on transthyretin expression was analyzed because γ-PKC mutants do not develop tolerance to chronic ethanol treatment. Ethanol treatment of mutants reversed the dramatic increase in transthyretin expression seen in naïve and control-diet treated mutants, but did not affect transthyretin expression in wild types.
Starting Page	869
Ending Page	881
Page Count	13
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	36
Issue Number	6
e-ISSN	15733297
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-06-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Protein kinase C Transthyretin Null mutant Mice Ethanol Evolutionary Biology Neurosciences Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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Microarray Analysis of the Effects of a γ-protein Kinase C Null Mutation on Gene Expression in Striatum: A Role for Transthyretin in Mutant Phenotypes

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Microarray Analysis of the Effects of a γ-protein Kinase C Null Mutation on Gene Expression in Striatum: A Role for Transthyretin in Mutant Phenotypes