NDLI: Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence

Content Provider	Springer Nature Link
Author	Dick, Danielle M. Aliev, Fazil Kramer, John Wang, Jen C. Hinrichs, Anthony Bertelsen, Sarah Kuperman, Sam Schuckit, Marc Nurnberger Jr, John Edenberg, Howard J. Porjesz, Bernice Begleiter, Henri Hesselbrock, Victor Goate, Alison Bierut, Laura
Copyright Year	2006
Abstract	The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.
Starting Page	265
Ending Page	272
Page Count	8
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	37
Issue Number	2
e-ISSN	15733297
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-12-12
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Intelligence IQ CHRM2 Cognitive ability Genetics Association analyses Evolutionary Biology Neurosciences Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Linkage Analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) Sample

No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence

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A Cholinergic Receptor Gene (CHRM2) Affects Event-related Oscillations

Behavior Genetics Association Meeting Abstracts

Behavior Genetics Association Meeting: Abstracts

Behavior Genetics Association Meeting: Abstracts

Behavior Genetics Association Meeting Abstracts

Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence

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