NDLI: Twin Pair Resemblance for Psychiatric Hospitalization in the Swedish Twin Registry: A 32-year Follow-up Study of 29,602 Twin Pairs

Content Provider	Springer Nature Link
Author	Prescott, Carol A. Kuhn, Jonathan W. Pedersen, Nancy L.
Copyright Year	2007
Abstract	Allgulander et al. (Allgulander C, Nowak J, Rice JP (1991) Acta Psychiatr Scand 83, 12) published twin pair analyses of psychiatric hospitalization for like-sex pairs from the Swedish Twin Registry born 1926–1958. As noted in a subsequent letter (Allgulander C, Nowak J, Rice JP (1992) Acta Psychiatr Scand 86, 421), several features of the original study resulted in under-ascertainment of cases and underestimated heritability, particularly for alcoholism. The present report updates the prior results by using 17 additional years of follow-up, including members of opposite-sex twin pairs, and addressing biases arising from cohort effects and from excluding pairs with unknown zygosity.Registry records for 29,602 twin pairs born 1926–1958 were matched against national databases of psychiatric and medical hospitalizations from 1972–2000 to obtain ICD diagnostic codes. Zygosity was known for 10,903 opposite-sex pairs and 15,401 like-sex pairs who participated previously in research. Twin-pair resemblance and genetic and environmental variance proportions were estimated for hospitalization for alcoholism, affective disorders, psychosis, and (in females) anxiety disorders.Hospitalization rates during the ascertainment window were: alcoholism: males = 3.67%, females = 0.94%; affective disorders: males = 1.99%, females = 2.75%; anxiety disorders: males = 0.46%, females = 0.74%; and psychotic disorders: males = 1.70%, females = 1.96%. Twins from like-sex pairs with unknown zygosity had significantly higher prevalences than those with known zygosity. Tetrachoric correlations and heritability estimates were affected by the method used to model unknown zygosity and cohort effects.Inclusion of additional follow-up information, opposite-sex twin pairs, age-adjustment, and use of current ICD definitions yielded higher heritability estimates for alcoholism, anxiety disorders, and psychosis than previously published for this nationally-representative sample of twins from Sweden. The results show that relatively small selection biases can alter twin study results and underscore the importance of addressing under-ascertainment of cases in genetic research based on volunteers.
Starting Page	547
Ending Page	558
Page Count	12
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	37
Issue Number	4
e-ISSN	15733297
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-04-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alcoholism Depression Psychosis Anxiety Ascertainment Evolutionary Biology Neurosciences Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Genetic Basis of Problem Behavior in 5-Year-Old Dutch Twin Pairs

Self-Reported Zygosity and the Equal-Environments Assumption for Psychiatric Disorders in the Vietnam Era Twin Registry

The Influence of Twin Pair Permutation on Likelihood-Based-Estimates of Genetic Variance That Require Ordering of Twin-Pairs

Ascertainment of a Twin Sample by Computerized Record Matching, with Assessment of Possible Sampling Biases

Physical Similarity and Twin Resemblance for Eating Attitudes and Behaviors: A Test of the Equal Environments Assumption

Effects of Chorion Type on Neonatal Temperament Differences in Monozygotic Twin Pairs

A Genetic Analysis of the Eating and Attitudes Associated with Bulimia Nervosa: Dealing with the Problem of Ascertainment in Twin Studies

Half of the Variation in Susceptibility to Mortality Is Genetic: Findings from Swedish Twin Survival Data

Genetic and Environmental Contributions to the Correlation Between Alcohol Consumption and Symptoms of Anxiety and Depression. Results from a Bivariate Analysis of Norwegian Twin Data

Twin Pair Resemblance for Psychiatric Hospitalization in the Swedish Twin Registry: A 32-year Follow-up Study of 29,602 Twin Pairs

Similar Documents

The Genetic Basis of Problem Behavior in 5-Year-Old Dutch Twin Pairs

Self-Reported Zygosity and the Equal-Environments Assumption for Psychiatric Disorders in the Vietnam Era Twin Registry

The Influence of Twin Pair Permutation on Likelihood-Based-Estimates of Genetic Variance That Require Ordering of Twin-Pairs

Ascertainment of a Twin Sample by Computerized Record Matching, with Assessment of Possible Sampling Biases

Physical Similarity and Twin Resemblance for Eating Attitudes and Behaviors: A Test of the Equal Environments Assumption

Effects of Chorion Type on Neonatal Temperament Differences in Monozygotic Twin Pairs

A Genetic Analysis of the Eating and Attitudes Associated with Bulimia Nervosa: Dealing with the Problem of Ascertainment in Twin Studies

Half of the Variation in Susceptibility to Mortality Is Genetic: Findings from Swedish Twin Survival Data

Genetic and Environmental Contributions to the Correlation Between Alcohol Consumption and Symptoms of Anxiety and Depression. Results from a Bivariate Analysis of Norwegian Twin Data

Twin Pair Resemblance for Psychiatric Hospitalization in the Swedish Twin Registry: A 32-year Follow-up Study of 29,602 Twin Pairs