NDLI: Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

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Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

Behavior Genetics Association 38th Annual Meeting Abstracts

Minutes of the Annual Business Meeting of the Members of the Behavior Genetics Association : Saturday, June 28, 2008, 16:00–16:45, Combs Chandler, Galt House Hotel in Louisville, Kentucky

Awards Presented at the 38th Annual Meeting of the Behavior Genetics Association : Saturday, June 28, 2008, Louisville, KY

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Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

Content Provider	Springer Nature Link
Author	Rose, Claudia Röhl, Friedrich Wilhelm Hanke, Joachim Schwegler, Herbert Yilmazer Hanke, Deniz M.
Copyright Year	2008
Abstract	In the present study, reciprocal embryo transfers were conducted to examine genetic and maternal effects on the baseline and fear-sensitized acoustic startle response (ASR) in the two inbred strains C3H/HeN and DBA/2JHd and the outbred strain NMRI. The largest differences in the ASR were found in untreated strains (effect size 0.6). The transfer procedure per se had a significant effect on the behavior of NMRI mice resulting in a reduction in the baseline, and an increase in the fear-sensitized ASR. In contrast, there were no significant effects of the transfer procedure in the two inbred strains. Autosomal genetic effects had a stronger impact on the amplitude of the ASR (effect sizes 0.5) than sex (effect sizes 0.06) as revealed by reciprocal embryo transfer. Nevertheless, the genetic effects on the fear-sensitized ASR were somewhat more variable and strain-dependent (effect sizes 0.1–0.2). Global maternal effects were detected after embryo transfer into NMRI mothers resulting in a larger reduction of the ASR in the offspring of DBA and NMRI donors than C3H donors (effect sizes 0.1–0.2). An additional fostering procedure was introduced to dissect uterine and postnatal maternal effects in NMRI offspring. Uterine factors changed the baseline ASR of the offspring in direction of the recipient mother strain. Surprisingly, postnatal maternal effects on the ASR were contrary to the behavior of the rearing mother. In conclusion, both genetic and prenatal/postnatal maternal factors persistently influenced the ASR of the offspring, whereas the fear-sensitized ASR was mainly influenced by genetic factors. Our study shows that uterine and postnatal maternal influences deserve more attention when determining the phenotype of genetically engineered mice at least in the first generation following embryo transfer.
Starting Page	596
Ending Page	611
Page Count	16
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	38
Issue Number	6
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2008-08-22
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Embryo transfer Genetic background Maternal effects Uterine effects Fostering Fear-sensitized acoustic startle response Sex Power analysis Effect size Health Psychology Clinical Psychology Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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