NDLI: Spurious Associations in Unreplicated Selected Lines

Content Provider	Springer Nature Link
Author	Henderson, rman D.
Copyright Year	1997
Abstract	Often a single pair of lines that has been selected for high and low expression of a trait is used as an animal model to study new biobehavioral characters thought to be associated with the selected trait. Because of genetic drift at many loci, comparisons of High and Low lines on the new character will frequently produce significant line differences even when there is no association between the selected trait and the new character being studied. In the absence of replicate lines to estimate the degree of genetic drift, effect size can be used to reduce the number of false-positive associations between the original selected trait and the new character. When the heritability of the new character exceeds .40 and the inbreeding coefficient within the selected lines is moderate, High- and Low-line means on the new character will frequently differ by at least one phenotypic SD, but not often differ by more than two SDs, in the absence of any relationship between the selected trait and the new character. If the selected lines are highly inbred, drift effects are greater, resulting in more false-positive associations. Situations posing special difficulty in the absence of replicate lines include the study of characters with low heritability relative to the selected trait and cases in which the lines do not differ greatly on the original selected trait. Studies using selected lines should always report inbreeding coefficients of the generations being studied, relative to the base population from which the lines were derived.
Starting Page	145
Ending Page	154
Page Count	10
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	27
Issue Number	2
e-ISSN	15733297
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Neurosciences Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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