NDLI: Regulatory Role of Nitric Oxide in Neutrophil Apoptosis

Content Provider	Springer Nature Link
Author	Stepovaya, Ye. A. Zhavorok, T. V. Starikov, Yu. V. Bychkov, V. A. Chasovskih, N. Yu. Starikova, Ye. G. Petina, G. V. vitsky, V. V. Ryazantseva, N. V.
Copyright Year	2008
Abstract	Apoptosis of blood neutrophils from healthy donors was studied under conditions of cell culturing with different concentrations of H2O2, selective NO synthase inhibitor, and inductor of NO synthesis (L-arginine). In vitro incubation of neutrophilic leukocytes with 5 mM H2O2 led to activation of the apoptotic program in neutrophils, which was seen from increased content of Bax protein in the cells and increased number of apoptotic cells in the culture. Increased content of annexin-positive cells after incubation of neutrophil culture with NO synthase inhibitor suggests involvement of NO in the regulation of neutrophil apoptosis under conditions of oxidative stress, while L-arginine prevented H2O2-induced programmed cell death.
Starting Page	737
Ending Page	740
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	146
Issue Number	6
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2009-04-29
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	nitric oxide apoptosis neutrophils active oxygen forms oxidative stress Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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