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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhanataev, A. K. Lisitsina, T. A. Durnev, A. D. |
| Copyright Year | 2006 |
| Abstract | Using the method of semiquantitative reverse transcription PCR we studied the expression of hOGG1 gene (exons 1–4 and 1–7) in peripheral blood cells from patients with systemic lupus erythematosus. Expression of this gene was disturbed in 9 of 18 patients (50%). In two patients mRNA of this gene was not expressed. In 5 patients hOGG1 mRNA was practically absent and was detected only after 35 amplification cycles. Suppression of exons 4–7 expression was detected in two of these cases and expression of both mRNA fragments (exons 1–4 and 4–7) was suppressed in 3 cases. In two patients a decrease in the relative content of exons 4–7 mRNA was found against the background of normal level of mRNA for exons 1–4. In none of the patients changes in the sequence of hOGG1 mRNA exons were revealed by parallel DGGE analysis. Our findings attest to disturbances in the expression of hOGG1 gene, primarily α-hOGG1 isoforms of the enzyme, in peripheral blood cells in patients with systemic lupus erythematosus. |
| Starting Page | 230 |
| Ending Page | 233 |
| Page Count | 4 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 142 |
| Issue Number | 2 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Consultants Bureau |
| Publisher Date | 2006-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | systemic lupus erythematosus DNA repair hOGG1 8-hydroxyguanine DNA glycosylase DGGE analysis Biomedicine general Laboratory Medicine Internal Medicine Pathology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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