NDLI: Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus

Content Provider	Springer Nature Link
Author	Dygai, A. M. Skurikhin, E. G. Pershina, O. V. Ermakova, N. N. Krupin, V. A. Ermolaeva, L. A. Stakheeva, M. N. Choinzov, E. L. Goldberg, V. E. Reikhart, D. V. Ellinidi, V. N. Kravtsov, V. Yu.
Copyright Year	2016
Abstract	The model of streptozotocin-induced diabetes mellitus in C57Bl/6 mice was employed to study the role of precursors of insulin-producing β-cells, hematopoietic stem cells, and progenitor hematopoietic cells in inflammation. In addition to provoking hyperglycemia, streptozotocin elevated serum levels of IL-1β and hyaluronic acid, induced edema in the pancreatic insular tissue and its infiltration by inflammatory cells (neutrophils, lymphocytes, and macrophages) and fibroblasts. Inflammation in pancreatic islets was accompanied by necrotic processes and decreasing counts of multipotent progenitor β-cells (CD45–, TER119–, c-kit-1–, and Flk-1–), oligopotent progenitor β-cells (CD45–, TER119–, CD133+, and CD49flow), and insulinproducing β-cells (Pdx1+). Pancreatic infl ammation was preceded by elevation of the number of short-term hematopoietic stem cells (Lin–Sca-1+c-kit+CD34+) relative to long-term cells (Lin–Sca-1+c-kit+CD34–) in the bone marrow as well as recruitment of hematopoietic stem and progenitor cells into circulation. Transplantation of bone marrow hematopoietic stem and progenitor cells from diabetic C57Bl/6 donor mice to recipient CBA mice with 5-fluorouracilinduced leukopenia accelerated regeneration of granulocytopoiesis in recipient mice.
Starting Page	474
Ending Page	479
Page Count	6
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	160
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2016-02-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	hematopoietic stem cells multipotent precursors of β-cells hyaluronic acid IL-1β diabetic inflammation Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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