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| Content Provider | Springer Nature Link |
|---|---|
| Author | Abramochkin, D. V. Moiseenko, L. S. Kuzmin, V. S. |
| Copyright Year | 2009 |
| Abstract | Changes in the configuration of action potentials and in the frequency of pacemaker discharges in a preparation of isolated rat right atrium under the effect of sodium hydrosulfide degrading in water solution with hydrogen sulfide release were studied by intracellular recording of action potentials in the myocardium. Sodium hydrosulfide in concentrations of 100–500 μM markedly reduced the duration of action potentials at the level of 50 and 90% repolarization and decelerated the sinus rhythm. Moreover, sodium hydrosulfide shortened action potentials in the preparations working in the forced rhythm. Glybenclamide (potassium ATP-dependent channel blocker; 10 μM) reduced the effect sodium hydrosulfide (200 μM) by more than 60%, which suggested the involvement of potassium ATP-dependent current in the realization of the effect of hydrogen sulfide on configuration of action potentials. Hence, hydrogen sulfide, recently described as a signal compound, modulates many electrophysiological parameters of the myocardium. |
| Starting Page | 683 |
| Ending Page | 686 |
| Page Count | 4 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 147 |
| Issue Number | 6 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-10-30 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | hydrogen sulfide atria action potential potassium ATP-dependent channels glybenclamide Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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