NDLI: Effect of Activated Peripheral κ-Opioid Receptors on the Action of Nicotine and its Withdrawal in Nicotine-Dependent Rats

Content Provider	Springer Nature Link
Author	Sudakov, S. K. Nazarova, G. A. Alekseeva, E. V. Kolpakov, A. A.
Copyright Year	2014
Abstract	We studied the possibilities of modulating the effects of nicotine and its withdrawal in nicotine-dependent rats by peripheral injection of κ-opioid receptor agonist ICI 204,448. Injection of nicotine to rats previously treated with nicotine for 14 days reduced motor activity, suppressed metabolism, and increased food intake. In rats receiving ICI 204,448 after chronic administration of nicotine, food intake did not differ from that in control animals receiving isotonic NaCl solution. ICI 204,448 had virtually no effect on suppression of motor activity and metabolism. The rats receiving the last injection of nicotine 24 h prior to the experiment demonstrated an increase in metabolism, locomotor activity, and food intake. In these animals, ICI 204,448 completely abolished the effects of nicotine withdrawal. It was found that peripheral administration of compound ICI 204,448 did not signifi cantly inhibit the effect of nicotine in nicotine-dependent rats, but abolished symptoms of nicotine withdrawal. It can be hypothesized that nicotine withdrawal syndrome is related to inhibition of dopamine release in the nucleus accumbens probably caused by enhanced κ-opioid activity in presynaptic terminals. Activation of peripheral κ-opioid receptors apparently suppressed (via vagal afferent pathways) central κ-opioid activity and reduced nicotine withdrawal symptoms in nicotine-dependent subjects.
Starting Page	609
Ending Page	611
Page Count	3
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	156
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2014-03-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	κ-opioid receptors nicotine metabolism feeding behavior motor activity Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Activation of Peripheral κ-Opioid Receptors Normalizes Caffeine Effects Modified in Nicotine-Dependent Rats during Nicotine Withdrawal

Effect of Activated Peripheral κ-Opioid Receptors on the Action of Nicotine and its Withdrawal in Nicotine-Dependent Rats

Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats

Changes in Feeding Behavior, Locomotor Activity, and Metabolism in Rats upon Modulation of Opioid Receptors in the Gastrointestinal Tract

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

Effect of Peripheral D2 Dopamine Receptor Antagonist Domperidone on Metabolism, Feeding Behavior, and Locomotor Activity of Rats

Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation

Methylnaloxone suppresses the development of withdrawal syndrome in morphine-dependent rats

Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol

Effect of Activated Peripheral κ-Opioid Receptors on the Action of Nicotine and its Withdrawal in Nicotine-Dependent Rats

Similar Documents

Activation of Peripheral κ-Opioid Receptors Normalizes Caffeine Effects Modified in Nicotine-Dependent Rats during Nicotine Withdrawal

Effect of Activated Peripheral κ-Opioid Receptors on the Action of Nicotine and its Withdrawal in Nicotine-Dependent Rats

Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats

Changes in Feeding Behavior, Locomotor Activity, and Metabolism in Rats upon Modulation of Opioid Receptors in the Gastrointestinal Tract

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

Effect of Peripheral D2 Dopamine Receptor Antagonist Domperidone on Metabolism, Feeding Behavior, and Locomotor Activity of Rats

Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation

Methylnaloxone suppresses the development of withdrawal syndrome in morphine-dependent rats

Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol

Effect of Activated Peripheral κ-Opioid Receptors on the Action of Nicotine and its Withdrawal in Nicotine-Dependent Rats