NDLI: Efficiency of Various Vitamin Doses for Polyhypovitaminosis Correction in Rats

Content Provider	Springer Nature Link
Author	Kodentsova, V. M. Vrzhesinskaya, O. A. Beketova, N. A. Kosheleva, O. V. Sokol’nikov, A. A.
Copyright Year	2014
Abstract	A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.1±1.1 g. The decrease in the levels of vitamins A and B2 in the liver and of 25-hydroxyvitamin D in the plasma of younger rats was more significant, this indicating their higher sensitivity to alimentary vitamin deficit. The increase in vitamin content in the ration to 100% over 5 days led to a significant body weight increment but did not restore vitamin levels in the liver, restoring, however, plasma levels of vitamins E and 25-hydroxyvitamin D. Addition of 50% vitamin content of the vitamin mixture for controls to vitamin-deficient rations of older rats for 2 weeks improved the levels of vitamins B1 and B2, but was virtually inessential for the liver content of vitamins A and E. High dose (158-200%) vitamins in animals of both age groups repaired the deficit of all vitamins, except vitamin A, despite the fact that its doses were the highest. These results validate long-term vitamin consumption for repair of their deficit.
Starting Page	608
Ending Page	611
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	157
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2014-09-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	combined vitamin deficit vitamins doses age rats Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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