NDLI: Modification of Collagen Formation by Mesenchymal Stem Cells Isolated from Human Adipose Tissue in Culture and after Autotransplantation for Abdominal Hernia Plasty

Content Provider	Springer Nature Link
Author	Bogdan, V. G. Zafranskaya, M. M. Gain, Yu. M. Demidchik, Yu. E. Bagatka, S. S. Ivanchik, G. I.
Copyright Year	2013
Abstract	Mesenchymal stem cells from the adipose tissue of patients with postoperative hernias produce excessive amounts of collagen III, which shifts the balance between type III and type I collagens. The proposed technique of pretransplantation preparation allows in vitro stimulation collagen formation processes with predominant activation of collagen I synthesis and normalization of proportion between different collagen types. Abdominal wall repair with polypropylene surgical mesh in combination with autotransplantation of mesenchymal stem cells reduced the collagen III to collagen I ratio due to activation of collagen I synthesis and suppression of collagen III production, which had a positive effect on the structure of in vivo formed connective tissue.
Starting Page	152
Ending Page	155
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	156
Issue Number	1
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2013-11-24
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	mesenchymal stem cells postoperative hernia collagen autotransplantation Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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Modification of Collagen Formation by Mesenchymal Stem Cells Isolated from Human Adipose Tissue in Culture and after Autotransplantation for Abdominal Hernia Plasty