NDLI: Effect of succinic acid and Tween-80 on glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine

Content Provider	Springer Nature Link
Author	Barav, P. A. Kravtsova, O. U. Sariev, A. K. Sherdev, V. P.
Copyright Year	2008
Abstract	We studied the effect of succinic acid on the process of glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine after peroral and intraperitoneal administration in the form of succinate or a base. Since the basic form of 2-ethyl-6-methyl-3-hydroxypyridine is insoluble in water, it was administered in 5% Tween-80. It was necessary to evaluate also the effect of Tween-80 on glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine in different administration routes. Quantitative assay of glucuronidated fractions was performed by the method of reversed-phase HPLC with fluorometrical detection. The detection limit for this method was 10 ng/ml. We confirmed that the major excretion pathway for 2-ethyl-6-methyl-3-hydroxypyridine is conjugation with glucuronic acid. It was found that succinic acid increased excretion of glucuronidated metabolite after both peroral and intraperitoneal administration of 2-ethyl-6-methyl-3-hydroxypyridine in the form of succinate and base in 5% Tween-80. The effect of Tween-80 was detected only after peroral administration, which was probably related to its effect on absorption of this compound. Tween-80 increased excretion of glucuronate after peroral administration of 2-ethyl-6-methyl-3-hydroxypyridine in the form of succinate and in 5% Tween solution.
Starting Page	56
Ending Page	58
Page Count	3
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	146
Issue Number	1
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2008-11-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	succinic acid Tween-80 2-ethyl-6-methyl-3-hydroxypyridine glucuronidation Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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