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| Content Provider | Springer Nature Link |
|---|---|
| Author | Reinyuk, V. L. Shefer, T. V. Ivnitskii, Yu. Yu. |
| Copyright Year | 2006 |
| Abstract | In rats with experimental thiopental coma rectal temperature decreased by 9.4°C, oxygen consumption 5-fold, and arteriovenous Po2 gradient decreased 2-fold within 3 h; CO2 accumulated in the blood and mixed type acidosis developed. Administration of sodium succinate under these conditions increased arteriovenous Po2 gradient and reduced manifestations of metabolic acidosis. Maintenance of normal body temperature (warming) corrected primarily manifestations of respiratory acidosis. Each therapeutic agent reduced inhibition of O2 consumption by 1/4; animal survival tended to increase from 42 to 50%. Combined use of these treatments potentiated the antiacidotic effect and increased survival to 92%. The authors conclude that hypothermia inhibits the therapeutic effect of succinate in barbiturate coma. |
| Starting Page | 57 |
| Ending Page | 60 |
| Page Count | 4 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 142 |
| Issue Number | 1 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Consultants Bureau |
| Publisher Date | 2006-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | barbiturate intoxication hypothermia oxygen consumption acid base status sodium succinate Biomedicine general Laboratory Medicine Internal Medicine Pathology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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