NDLI: Signaling Events during Macrophage Activation with Betula pendula Roth Pectic Polysaccharides

Content Provider	Springer Nature Link
Author	Ligacheva, A. A. Danilets, M. G. Trofimova, E. S. Belsky, Y. P. Belska, N. V. Zyuz’kov, G. N. Zhdav, V. V. Ivava, A. N. Guriev, A. M. Belousov, M. V. Yusubov, M. S. Dygai, A. M.
Copyright Year	2014
Abstract	We studied the effect of two pectic polysaccharides PS-B1-AG and PS-B2-RG that were contained in total polysaccharides extracted from Betula pendula leaves on NO production by mouse macrophages and the contribution of signaling molecules to macrophage activation by the test substances. Unlike the total sample, pectins produced a NO-stimulating effect on macrophages. The effect of PS-B2-RG (10 μg/ml) did not differ from the effect of LPS, while PS-B1-AG produced this effect only in a concentration of 20 μg/ml, which was probably due to differences in the chemical structure of the test substances. The studied pectin polysaccharides activated transcription factor NF-κB, kinases p38 and PI3, and cAMP as a negative regulator. These results indicate that Betula pendula polysaccharides are promising substances for creation of immunomodulating drugs.
Starting Page	465
Ending Page	469
Page Count	5
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	156
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2014-03-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	macrophages nitric oxide signaling molecules plant polysaccharides immune response Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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