NDLI: Study of Cytokine Profile and Angiogenic Potential of Peritoneal Fluid in Patients with External Genital Endometriosis

Content Provider	Springer Nature Link
Author	Sokolov, D. I. Solodovnikova, N. G. Pavlov, O. V. Niauri, D. A. Volkov, N. N. Sel'kov, S. A.
Copyright Year	2005
Abstract	The concentrations of proinflammatory cytokines (IL-1β, IL-6), vascular endothelium growth factor, tumor growth factor-β, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid from patients with external genital endometriosis on proliferative activity of EA.Hy926 human endothelial cells was evaluated by the method based on the analysis of cell cycle by flow cytometry. The concentrations of IL-1β, IL-6, and insulin-like growth factor-1 were increased in patients with endometriosis in comparison with healthy women. The peritoneal fluid from patients with endometriosis (but not from healthy women) significantly increased mitotic activity of endothelial cells and exhibited high angiogenic potential, which can promote implantation and growth of endometrial transplants. Presumably, insulin-like growth factor-1 stimulates this process.
Starting Page	541
Ending Page	544
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	140
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Kluwer Academic Publishers-Consultants Bureau
Publisher Date	2005-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	endometriosis angiogenesis growth factors insulin-like growth factor Laboratory Medicine Internal Medicine Cell Biology Biomedicine general Pathology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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