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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhukova, N. A. Semev, D. E. Bessergeneva, E. P. Sorokina, I. V. Tolstikova, T. G. |
| Copyright Year | 2013 |
| Abstract | The hepatoprotective effects of new triterpene derivatives, betulin 3β,28-di-O-nicotinate (of3) and 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15), were studied in CBA/Lac mice with transplanted RLS lymphoma receiving polychemotherapy and without it. Injection of of3 and of15 agents to animals with tumors receiving polychemotherapy reduced the severity of toxic involvement of the liver, reduced mitotic activity of tumor cells in the primary node in animals receiving and not polychemotherapy, and produced a moderate antitumor effect. These effects were more pronounced for of15 agent. In addition, injection of agents of3 and of5 to animals with transplanted RLS lymphoma reduced the intensity of alterations associated with the total systems and local effects of the neoplastic process. |
| Starting Page | 370 |
| Ending Page | 374 |
| Page Count | 5 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 154 |
| Issue Number | 3 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-01-16 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | RLS lymphoma metastases to mouse liver polychemotherapy hepatoprotective effect betulin 3β,28-di-O-nicotinate (of3) 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15) Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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