NDLI: Experimental modeling of preclinical and clinical stages of Parkinson’s disease

Content Provider	Springer Nature Link
Author	Khaindrava, V. G. Kozina, E. A. Kudrin, V. S. Kucheryanu, V. G. Klodt, P. D. Narkevich, V. B. Bocharov, E. V. Nanaev, A. K. Kryzhavsky, G. N. Raevskii, K. S. Ugrumov, M. V.
Copyright Year	2011
Abstract	Degeneration of dopaminergic (DAergic) neurons of the nigrostriatal system is the key stage in the pathogenesis of Parkinson’s disease. The fi rst symptoms of this disease are observed after degeneration of 70-80% neurons, which occurs over 20–30 years. The clinical stage of Parkinson’s disease begins after this period. Late diagnostics of Parkinson’s disease contributes to low effi ciency of therapi for this disorder. Detailed study of the pathogenesis and development of preclinical diagnostic methods for Parkinson’s disease are the urgent problems. This work was designed to develop a new experimental model of the preclinical and clinical stages of the disease. Experimental modeling was performed on C57Bl/6 mice using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This agent is converted into the MPP+−neurotoxin in brain DAergic neurons. We showed that MPTP in a dose of 4 mg/kg has no effect on the nigrostriatal DAergic system. MPTP in a dose of 8–16 mg/kg produced the toxic effect only on DAergic axons, which simulates the preclinical stage of Parkinson’s disease. MPTP in a dose of 20–40 mg/kg had the toxic effect on neuronal axons and bodies, which simulates the clinical stage of Parkinson’s disease. The data suggest that progressive degeneration of DAergic neurons is accompanied by activation of compensatory mechanisms for functional defi ciency of these cells.
Starting Page	566
Ending Page	569
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	150
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2011-03-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	brain dopamine substantia nigra tyrosine hydroxylase neurotoxin Internal Medicine Biomedicine general Cell Biology Laboratory Medicine Pathology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Degeneration of nigrostriatal dopaminergic neurons in an experimental model of the early clinical stage of Parkinson’s disease

Quantitative Morphochemical Characterization of the Neurons in Substantia Nigra of Rat Brain and Its Volume Reconstruction

Experimental Modeling of Functional Deficiency of the Nigrostriatal Dopaminergic System in Mice

Compensatory Changes in the Brain Dopaminergic System of WAG/Rij Rats Genetically Predisposed to Absence Epilepsy

Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson’s disease

Effect of ethanol consumption on the expression of the tyrosine hydroxylase gene in rat brain and adrenals

Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine

Activity of Monoamine Oxidase in the Nigrostriatal System at Presymptomatic and Early Symptomatic Stages of Parkinsonism in Mice

Effects of Short-Term Exposure to Haloperidol and Reserpine on Dopamine Turnover in Nigrostriatal System in Rat Brain

Experimental modeling of preclinical and clinical stages of Parkinson’s disease

Similar Documents

Degeneration of nigrostriatal dopaminergic neurons in an experimental model of the early clinical stage of Parkinson’s disease

Quantitative Morphochemical Characterization of the Neurons in Substantia Nigra of Rat Brain and Its Volume Reconstruction

Experimental Modeling of Functional Deficiency of the Nigrostriatal Dopaminergic System in Mice

Compensatory Changes in the Brain Dopaminergic System of WAG/Rij Rats Genetically Predisposed to Absence Epilepsy

Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson’s disease

Effect of ethanol consumption on the expression of the tyrosine hydroxylase gene in rat brain and adrenals

Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine

Activity of Monoamine Oxidase in the Nigrostriatal System at Presymptomatic and Early Symptomatic Stages of Parkinsonism in Mice

Effects of Short-Term Exposure to Haloperidol and Reserpine on Dopamine Turnover in Nigrostriatal System in Rat Brain

Experimental modeling of preclinical and clinical stages of Parkinson’s disease