NDLI: Expression of genes involved in the early immune response at the distal segment of the gut in Atlantic cod, Gadus morhua L. after vaccination with a bacterial antigen

Content Provider	Springer Nature Link
Author	Caipang, Christopher Marlowe A.
Copyright Year	2012
Abstract	The gastro-intestinal tract serves as the route of infection of most bacterial pathogens in fish, and the immune response genes in the gut produce substances that provide an initial defense during pathogen invasion. The expression of some genes involved in antibacterial defense, cell-mediated immunity and inflammation in the distal intestine of Atlantic cod, Gadus morhua L., was investigated following intraperitoneal vaccination with heat-killed Vibrio anguillarum. Tissue samples of the distal intestine were collected at 0, 1, 3, 7 and 10 days post-vaccination (dpv) and processed for semi-quantitative RT-PCR analyses. Expression of the bactericidal/permeability-increasing protein/lipopolysaccharide-binding protein (BPI/LBP), g-type lysozyme, non-specific cytotoxic cell receptor protein-1 (NCCRP-1) and interleukin-8 (IL-8) significantly increased during the early stages post-vaccination, that is, 1–3 dpv, followed by a decrease in their expression returning to their initial levels. Transferrin and apolipoprotein A-I, although weakly expressed in the distal intestine, also increased in the vaccinated fish. Interleukin-1β (IL-1β) was significantly decreased in its expression level relative to the PBS-injected fish at 3 and 7 dpv. The expression of these immune-related genes in the distal intestine as a result of vaccination provides valuable information on the mechanisms of gut immunity in the fish against pathogenic bacteria, particularly during the early stages of infection.
Starting Page	591
Ending Page	603
Page Count	13
File Format	PDF
ISSN	09676120
Journal	Aquaculture International
Volume Number	21
Issue Number	3
e-ISSN	1573143X
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-09-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Atlantic cod Bacteria Gut Immune-related genes Vaccination Freshwater & Marine Ecology Zoology
Content Type	Text
Resource Type	Article
Subject	Aquatic Science Agronomy and Crop Science

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