NDLI: The death receptor DR5 is involved in TRAIL-mediated human osteoclast apoptosis

Content Provider	Springer Nature Link
Author	Colucci, Silvia Brunetti, Giacomina Cantatore, Francesco Paolo Oranger, Angela Mori, Giorgio Pignataro, Paolo Tamma, Roberto Grassi, Felice Roberto Zallone, Alberta Gra, Maria
Copyright Year	2007
Abstract	The number and activity of osteoclasts (OCs) are critical for maintaining normal bone turnover. The number is determined by the rates of cell differentiation and death. TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, induces apoptosis by interacting with its death receptors, (DR4, DR5). However, its activity can be modulated by two decoy receptors, (DcR1 and DcR2). In this paper we show that TRAIL treatment causes reduced OC viability as well as an increased apoptotic OC number. Loss of nuclei integrity and derangement of the actin microfilament were also induced by TRAIL in OCs. Moreover, we demonstrated the expression of all TRAIL receptors in both precursors and differentiated OCs, and the upregulation of DR5 during OC differentiation. Interestingly, DcR2 was upregulated in the early stage of osteoclastogenesis and downregulated at the end of the differentiation process. We showed that DR5, upregulated by TRAIL, could be the mediator of TRAIL-induced OC apoptosis, since the addition of anti-DR5 neutralizing antibodies restores the OC viability previously reduced by TRAIL. Furthermore, the intracellular pathway induced by TRAIL in OCs involves caspase-8 and Bid activation. In conclusion, our data highlight an important role for the TRAIL/TRAIL receptor system in the regulation of OC apoptosis.
Starting Page	1623
Ending Page	1632
Page Count	10
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	12
Issue Number	9
e-ISSN	1573675X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-06-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TRAIL TRAIL receptors Osteoclasts Apoptosis Caspase-8 Bid Virology Biochemistry Oncology Cell Biology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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