NDLI: Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1

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Apoptosis : Volume 12, Issue 2, February 2007

Apoptosis : Volume 12, Issue 1, January 2007

Apoptosis : Volume 11

Apoptosis : Volume 10

Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1

Content Provider	Springer Nature Link
Author	Chau, David H. W. Yuan, Ji Zhang, Huifang Cheung, Paul Lim, Travis Liu, Zhen Sall, Alhousseyu Yang, Decheng
Copyright Year	2006
Abstract	By transfection of Coxsackievirus B3 (CVB3) individual protease gene into HeLa cells, we demonstrated that 2Apro and 3Cpro induced apoptosis through multiple converging pathways. Firstly, both 2Apro and 3Cpro induced caspase-8-mediated activation of caspase-3 and dramatically reduced cell viability. Secondly, they both activated the intrinsic mitochondria-mediated apoptosis pathway leading to cytochrome c release from mitochondria and activation of caspase-9. However, 3Cpro induced these events via both up-regulation of Bax and cleavage of Bid, and 2Apro induced these events via cleavage of Bid only. Nevertheless, neither altered Bcl-2 expression. Thirdly, both proteases induced cell death through cleavage or down regulation of cellular factors for translation and transcription: both 2Apro and 3Cpro cleaved eukaryotic translation initiation factor 4GI but their cleavage products are different, indicating different cleavage sites; further, both 2Apro and 3Cpro down-regulated cyclic AMP responsive element binding protein, a transcription factor, with 2Apro exhibiting a stronger effect than 3Cpro. Surprisingly, neither could cleave DAP5/p97/NAT1, a translation regulator, although this cleavage was observed during CVB3 infection and could not be blocked by caspase inhibitor z-VAD-fmk. Taken together, these data suggest that 2Apro and 3Cpro induce apoptosis through both activation of proapoptotic mediators and suppression of translation and transcription.
Starting Page	513
Ending Page	524
Page Count	12
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	12
Issue Number	3
e-ISSN	1573675X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-12-29
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Apoptosis Protease 2A Protease 3C DAP5/p97/NAT1 eIF4GI CREB Coxsackievirus B3 Virology Biochemistry Cell Biology Cancer Research Oncology
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through a mitochondria-mediated pathway and cleavage of host factors for transcription and translation initiation

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