NDLI: Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis

Content Provider	Springer Nature Link
Author	Scheel Toellner, Dagmar Raza, Karim Assi, Lakhvir Pilling, Darrell Ross, Emma J. Lee, Wing Yiu Curw, S. John Buckley, Christopher D. Akbar, Arne N. Lord, Janet M. Salmon, Mike
Copyright Year	2007
Abstract	Activated T cells require anti-apoptotic cytokines for their survival. The anti-apoptotic effects of these factors are mediated by their influence on the balance of expression and localisation of pro- and anti-apoptotic members of the Bcl-2 family. Among the anti-apoptotic Bcl-2 family members, the expression level of Bcl-2 itself and its interaction with the pro-apoptotic protein Bim are now regarded as crucial for the regulation of survival in activated T cells. We studied the changes in Bcl-2 levels and its subcellular distribution in relation to mitochondrial depolarisation and caspase activation in survival factor deprived T cells. Intriguingly, the total Bcl-2 level appeared to remain stable, even after caspase 3 activation indicated entry into the execution phase of apoptosis. However, cell fractionation experiments showed that while the dominant nuclear pool of Bcl-2 remained stable during apoptosis, the level of the smaller mitochondrial pool was rapidly downregulated. Signals induced by anti-apoptotic cytokines continuously replenish the mitochondrial pool, but nuclear Bcl-2 is independent of such signals. Mitochondrial Bcl-2 is lost rapidly by a caspase independent mechanism in the absence of survival factors, in contrast only a small proportion of the nuclear pool of Bcl-2 is lost during the execution phase and this loss is a caspase dependent process. We conclude that these two intracellular pools of Bcl-2 are regulated through different mechanisms and only the cytokine-mediated regulation of the mitochondrial pool is relevant to the control of the initiation of apoptosis.
Starting Page	109
Ending Page	117
Page Count	9
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	13
Issue Number	1
e-ISSN	1573675X
Language	English
Publisher	Springer US
Publisher Date	2007-10-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bcl-2 Cytokines Survival Lymphocytes Programmed cell death Virology Biochemistry Oncology Cell Biology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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