NDLI: Mechanisms of B cell receptor induced apoptosis

Content Provider	Springer Nature Link
Author	Eeva, J. Pelkonen, J.
Copyright Year	2004
Abstract	B cell receptor (BCR)-mediated apoptosis plays a key role in the negative selection (deletion) of autoreactive B cells. Mechanisms of BCR-mediated apoptosis have been widely studied in cell lines representing both immature (bone marrow) and mature (germinal center) B cells. However, there is much inconsistency and controversy concerning the possible mechanisms of BCR-mediated apoptosis, which may reflect differences in the origin or the maturational stage of the cell line used. Based on recent studies, collapse of mitochondrial membrane potential (Δ Ψ m) seems to be an essential event for BCR-mediated apoptosis in both mature and immature cells. The collapse of Δ Ψ m is dependent on the synthesis of new proteins, which are involved in the permeability change of mitochondrial membranes. Mitochondrial dysfunction induces activation of caspases, cysteine proteases, which play a central role in apoptosis. However, instead of caspases, other effector proteases, such as cathepsins or calpains, may also be responsible for the organized destruction of cell components seen during BCR-mediated apoptosis.
Starting Page	525
Ending Page	531
Page Count	7
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	9
Issue Number	5
e-ISSN	1573675X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cancer Research Virology Anatomy Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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