NDLI: Apyrase Activity and Platelet Aggregation Inhibitors in the Tick Ornithodoros Savignyi (Acari: Argasidae)

Content Provider	Springer Nature Link
Author	Mans, B.J. Gaspar, A.R.M.D. Louw, A.I. Neitz, A.W.H.
Copyright Year	1998
Abstract	Ticks are ectoparasites that cause considerable damage to their hosts while feeding. The feeding process is facilitated by anti-haemostatic factors present in the tick saliva. Apyrase (ATP diphosphohydrolase, EC 3.6.1.5) is a platelet aggregation inhibitor found in most haematophagous organisms studied. The present study describes the identification and characterization of such an activity in the tick Ornithodoros savignyi. The enzyme conformed to many properties common to apyrases. These included a low substrate specificity, dependence on bivalent metal ions for activity and insensitivity to the classical ATPase inhibitors. Heat denaturation studies, pH optima and similar effects of inhibitors on the enzyme's ATP and ADP hydrolysing activities supported its classification as an apyrase. Salivary gland extracts inhibited the platelet aggregation induced by ADP, collagen and thrombin and disaggregated aggregated platelets. The results suggest the presence of two or more anti-platelet factors present in the salivary glands of this tick species.
Starting Page	353
Ending Page	366
Page Count	14
File Format	PDF
ISSN	01688162
Journal	Experimental & Applied Acarology
Volume Number	22
Issue Number	6
e-ISSN	15729702
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Animal Systematics/Taxonomy/Biogeography
Content Type	Text
Resource Type	Article
Subject	Ecology Medicine Insect Science

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