NDLI: Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children

Content Provider	Springer Nature Link
Author	Homan, Matjaž Šterbenc, Anja Kocjan, Boštjan J. Luzar, Boštjan Zidar, Nina Orel, Rok Poljak, Mario
Copyright Year	2014
Abstract	The aims of our study were to determine the prevalence of the babA2 gene within Helicobacter pylori strains circulating in the Slovenian pediatric population, to further clarify its significance in causing inflammation of gastric mucosa in children and to verify whether cagA, vacA, iceA and babA genes work independently or synergistically in causing gastritis. A total of 163 H. pylori isolates obtained from the same number of children were tested for the presence of cagA, vacA and iceA genes using previously established methods, while the babA2 gene was determined using novel polymerase chain reaction assay targeting a 139-bp fragment of the central region of babA2. The babA2 gene was detected in 47.9 % of H. pylori samples. The presence of the babA2 gene was strongly associated with cagA, vacA s1 and vacA m1 genotype. The babA2 status correlated positively with bacterial density score, activity of inflammation and chronic inflammation of gastric mucosa. No significant correlation was found between the babA2 status and the presence of atrophy or intestinal metaplasia. In addition, the activity of gastric inflammation and density score were significantly associated with the coexpression of the cagA, vacA s1, vacA m1 and babA2 genes. The study, which included the largest number of pediatric H. pylori samples to date, confirmed that babA2 gene plays an important role in the pathogenesis of H. pylori gastritis in children. Furthermore, our results suggest that babA2, cagA and vacA s1 and m1 gene products may work synergistically in worsening the inflammation of gastric mucosa.
Starting Page	637
Ending Page	645
Page Count	9
File Format	PDF
ISSN	00036072
Journal	Antonie van Leeuwenhoek
Volume Number	106
Issue Number	4
e-ISSN	15729699
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-07-24
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Helicobacter pylori babA2 gene Gastritis Children Microbiology Medical Microbiology Plant Sciences Soil Science & Conservation
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Microbiology

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