NDLI: Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist

Content Provider	Springer Nature Link
Author	Jost, B. Helen Billington, Stephen J.
Copyright Year	2005
Abstract	Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically important livestock, causing diseases as diverse as mastitis, liver abscessation and pneumonia. This organism possesses a number of virulence factors that contribute to its pathogenic potential. A. pyogenes expresses a cholesterol-dependent cytolysin, pyolysin, which is a haemolysin and is cytolytic for immune cells, including macrophages. Expression of pyolysin is required for virulence and this molecule is the most promising vaccine candidate identified to date. A. pyogenes also possesses a number of adherence mechanisms, including two neuraminidases, the action of which are required for full adhesion to epithelial cells, and several extracellular matrix-binding proteins, including a collagen-binding protein, which may be required for adhesion to collagen-rich tissue. A. pyogenes also expresses fimbriae, which are similar to the type 2 fimbriae of Actinomyces naeslundii, and forms biofilms. However, the role of these factors in the pathogenesis of A. pyogenes infections remains to be elucidated. A. pyogenes also invades and survives within epithelial cells and can survive within J774A.1 macrophages for up to 72 h, suggesting an important role for A. pyogenes interaction with host cells during pathogenesis. The two component regulatory system, PloSR, up-regulates pyolysin expression and biofilm formation but down-regulates expression of proteases, suggesting that it may act as a global regulator of A. pyogenes virulence. A. pyogenes is a versatile pathogen, with an arsenal of virulence determinants. However, most aspects of the pathogenesis of infection caused by this important opportunistic pathogen remain poorly characterized.
Starting Page	87
Ending Page	102
Page Count	16
File Format	PDF
ISSN	00036072
Journal	Antonie van Leeuwenhoek
Volume Number	88
Issue Number	2
e-ISSN	15729699
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adhesion Arcanobacterium pyogenes Cholesterol-dependent cytolysin Fimbriae Invasion Pathogenesis Soil Science & Conservation Medical Microbiology Microbiology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Microbiology

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