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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yegutkin, Gennady G. Helenius, Mikko Kaczmarek, Elzbieta Burns, Nana Jalkanen, Sirpa Stenmark, Kurt Gerasimovskaya, Evgenia V. |
| Copyright Year | 2011 |
| Abstract | Vascular remodeling plays a pivotal role in a variety of pathophysiological conditions where hypoxia and inflammation are prominent features. Intravascular ATP, ADP and adenosine are known as important regulators of vascular tone, permeability and homeostasis, however contribution of purinergic signalling to endothelial cell growth and angiogenesis remains poorly understood. By using vasa vasorum endothelial cells (VVEC) isolated from pulmonary artery adventitia of control and chronically hypoxic neonatal calves, these studies were aimed to evaluate the effect of hypoxia on biochemical and functional properties of microvascular endothelial network at the sites of angiogenesis. In comparison with normoxic controls, VVEC from hypoxic animals are characterized by (1) drastically impaired nucleoside triphosphate diphosphohydrolase-1 (NTPDase-1/CD39) and ecto-5′-nucleotidase/CD73 activities with respective increases in basal extracellular ATP and ADP levels (2) higher proliferative responses to low micromolar concentrations of ATP and ADP; and (3) enhanced permeability and disordered adenosinergic control of vascular barrier function (measured as a paracellular flux of 70 kDa fluorescein isothiocyanate-dextran). Together, these results suggest that unique pattern of purine-mediated angiogenic activation and enhanced leakiness of VVEC from chronically hypoxic vessels may be defined by disordered endothelial nucleotide homeostasis at sites of active neovascularization. |
| Starting Page | 503 |
| Ending Page | 513 |
| Page Count | 11 |
| File Format | |
| ISSN | 09696970 |
| Journal | Angiogenesis |
| Volume Number | 14 |
| Issue Number | 4 |
| e-ISSN | 15737209 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-09-16 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Purinergic signaling Endothelial cells Vasa vasorum Hypoxia NTPDase Ecto-5′-nucleotidase Cancer Research Cardiology Cell Biology Ophthalmology Biomedicine general Oncology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Clinical Biochemistry Cancer Research |
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