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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chaves, Madalena Tournier, Laurent Gouzé, Jean Luc |
| Copyright Year | 2010 |
| Abstract | Multi-level discrete models of genetic networks, or the more general piecewise affine differential models, provide qualitative information on the dynamics of the system, based on a small number of parameters (such as synthesis and degradation rates). Boolean models also provide qualitative information, but are based simply on the structure of interconnections. To explore the relationship between the two formalisms, a piecewise affine differential model and a Boolean model are compared, for the carbon starvation response network in E. coli. The asymptotic dynamics of both models are shown to be quite similar. This study suggests new tools for analysis and reduction of biological networks. |
| Starting Page | 217 |
| Ending Page | 232 |
| Page Count | 16 |
| File Format | |
| ISSN | 00015342 |
| Journal | Acta Biotheoretica |
| Volume Number | 58 |
| Issue Number | 2-3 |
| e-ISSN | 15728358 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2010-07-28 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Boolean models Piecewise affine models Genetic networks Model reduction Evolutionary Biology Philosophy of Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Philosophy Applied Mathematics Medicine Biochemistry, Genetics and Molecular Biology Environmental Science Agricultural and Biological Sciences |
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