NDLI: Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery

Content Provider	Springer Nature Link
Author	Sankaran, Sethuraman Esmaily Moghadam, Mahdi Kahn, Andrew M. Tseng, Elaine E. Guccione, Julius M. Marsden, Alison L.
Copyright Year	2012
Abstract	We present a computational framework for multiscale modeling and simulation of blood flow in coronary artery bypass graft (CABG) patients. Using this framework, only CT and non-invasive clinical measurements are required without the need to assume pressure and/or flow waveforms in the coronaries and we can capture global circulatory dynamics. We demonstrate this methodology in a case study of a patient with multiple CABGs. A patient-specific model of the blood vessels is constructed from CT image data to include the aorta, aortic branch vessels (brachiocephalic artery and carotids), the coronary arteries and multiple bypass grafts. The rest of the circulatory system is modeled using a lumped parameter network (LPN) 0 dimensional (0D) system comprised of resistances, capacitors (compliance), inductors (inertance), elastance and diodes (valves) that are tuned to match patient-specific clinical data. A finite element solver is used to compute blood flow and pressure in the 3D (3 dimensional) model, and this solver is implicitly coupled to the 0D LPN code at all inlets and outlets. By systematically parameterizing the graft geometry, we evaluate the influence of graft shape on the local hemodynamics, and global circulatory dynamics. Virtual manipulation of graft geometry is automated using Bezier splines and control points along the pathlines. Using this framework, we quantify wall shear stress, wall shear stress gradients and oscillatory shear index for different surgical geometries. We also compare pressures, flow rates and ventricular pressure–volume loops pre- and post-bypass graft surgery. We observe that PV loops do not change significantly after CABG but that both coronary perfusion and local hemodynamic parameters near the anastomosis region change substantially. Implications for future patient-specific optimization of CABG are discussed.
Starting Page	2228
Ending Page	2242
Page Count	15
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	40
Issue Number	10
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2012-04-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hemodynamics Bypass graft Wall shear stress Coronary artery Multiscale modeling Biochemistry Biomedical Engineering Biophysics and Biological Physics Biomedicine general Mechanics
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Human Saphenous Vein Coronary Artery Bypass Graft Morphology, Geometry and Hemodynamics

Effects of Vessel Tortuosity on Coronary Hemodynamics: An Idealized and Patient-Specific Computational Study

Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery

Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Patient-Specific Modeling of Blood Flow and Pressure in Human Coronary Arteries

Effect of Cell-Free Layer Variation on Arteriolar Wall Shear Stress

Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

Characterization of Abnormal Wall Shear Stress Using 4D Flow MRI in Human Bicuspid Aortopathy

Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery

Similar Documents

Human Saphenous Vein Coronary Artery Bypass Graft Morphology, Geometry and Hemodynamics

Effects of Vessel Tortuosity on Coronary Hemodynamics: An Idealized and Patient-Specific Computational Study

Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery

Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations

The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava

Patient-Specific Modeling of Blood Flow and Pressure in Human Coronary Arteries

Effect of Cell-Free Layer Variation on Arteriolar Wall Shear Stress

Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

Characterization of Abnormal Wall Shear Stress Using 4D Flow MRI in Human Bicuspid Aortopathy

Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery