NDLI: A Micromechanical Model of Airway-Parenchymal Interdependence

Content Provider	Springer Nature Link
Author	Adler, Andy Bates, Jason H. T.
Copyright Year	2000
Abstract	The forces of parenchymal interdependence in the lung are potent inhibitors of airway smooth muscle shortening, as evidenced by the marked dependence of bronchial responsiveness on lung volume. In this study we developed a mathematical-computer model of the effects of parenchymal interdependence on airway smooth muscle shortening. A three-dimensional network of cuboidal alveolar walls was tethered at its boundaries and surrounded a single airway with mechanical properties identical to the alveolar parenchyma. The walls were assigned highly nonlinear properties so that the pressure-volume behavior of the model matched that measured in dogs. Constriction of the airway was achieved by increasing the circumferential tension in the airway wall, and then solving the force-balance equations of the model to calculate the equilibrium configurations of the airway wall and all the interconnecting alveolar walls. The changes in airway resistance predicted by the model at various transpulmonary pressures (P tp were compared to those obtained by the alveolar capsule oscillator technique in dogs during induced bronchoconstriction at various P tp (Balassy et al., J. Appl. Physiol. 78:875–880, 1995). The model matched the data reasonably well at P tp values above about 0.5 kPa, but was too responsive at lower P tp We were able to make the model match the data at all P tpby including an additional stiffness term, such as might conceivably arise from the airway wall itself. ©
Starting Page	309
Ending Page	317
Page Count	9
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	28
Issue Number	3
e-ISSN	15739686
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Mechanics Biophysics/Biomedical Physics Vibration, Dynamical Systems, Control Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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