NDLI: Computational Investigation of the Delamination of Polymer Coatings During Stent Deployment

Content Provider	Springer Nature Link
Author	Hopkins, C. G. McHugh, P. E. McGarry, J. P.
Copyright Year	2010
Abstract	Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant mechanical challenge. Problems with coating delamination have been reported in recent experimental studies. In this paper, a cohesive zone model of the stent–coating interface is implemented in order to investigate coating debonding during stent deployment. Simulations reveal that coatings debond from the stent surface in tensile regions of the plastic hinge during deployment. The critical parameters governing the initiation of delamination include the coating thickness and stiffness, the interface strength between the coating and stent surface, and the curvature of the plastic hinge. The coating is also computed to debond from the stent surface in compressive regions of the plastic hinge by a buckling mechanism. Computed patterns of coating delamination correlate very closely with experimental images. This study provides insight into the critical factors governing coating delamination during stent deployment and offers a predictive framework that can be used to improve the design of coated stents.
Starting Page	2263
Ending Page	2273
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-03-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Polymer coating Stent deployment Delamination Cohesive zone Finite element Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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