NDLI: Design of a Modular Bioreactor to Incorporate Both Perfusion Flow and Hydrostatic Compression for Tissue Engineering Applications

Content Provider	Springer Nature Link
Author	Orr, David E. Burg, Karen J. L.
Copyright Year	2008
Abstract	Physiological models have demonstrated that cells undergo a cyclic regimen of hydrostatic compression and fluid shear stress within the lacunar-canalicular porosity of bone. A new modular bioreactor was designed to incorporate both perfusion fluid flow and hydrostatic compression in an effort to more accurately simulate the mechanical loading and stress found in natural bone in vivo. The bioreactor design incorporated custom and off-the-shelf components to produce levels of mechanical stimuli relevant to the physiologic range, including hydrostatic compression exceeding 300 kPa and perfusion shear stress of 0.7 dyne/cm2. Preliminary findings indicated that the novel system facilitated the viable growth of cells on discrete tissue engineering scaffolds. The bioreactor has established an experimental platform for ongoing investigation of the interactive effect of perfusion fluid flow and hydrostatic compression on multiple cell types.
Starting Page	1228
Ending Page	1241
Page Count	14
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	36
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2008-04-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bone Continuous scaffold Discrete scaffold Hydrostatic compression Shear stress Three-dimensional Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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