NDLI: Age-Dependent Ascending Aorta Mechanics Assessed Through Multiphase CT

Content Provider	Springer Nature Link
Author	Martin, Caitlin Sun, Wei Primia, Charles McKay, Raymond Elefteriades, John
Copyright Year	2013
Abstract	Quantification of the age- and gender-specific in vivo mechanical characteristics of the ascending aorta (AA) will allow for identification of abnormalities aside from changes brought on by aging alone. Multiphase clinical CT scans of 45 male patients between the ages of 30 and 79 years were analyzed to assess age-dependent in vivo AA characteristics. The three-dimensional AA geometry for each patient was reconstructed from the CT scans for 9–10 phases throughout the cardiac cycle. The AA circumference was measured during each phase and was used to determine the corresponding diameter, circumferential strain, and wall tension at each phase. The pressure-strain modulus was also determined for each patient. The mean diastolic AA diameter was significantly smaller among young (42.6 ± 5.2 years) at 29.9 ± 2.8 mm than old patients (69.0 ± 5.2 years) at 33.2 ± 3.2 mm. The circumferential AA strain from end-diastole to peak-systole decreased from 0.092 ± 0.03 in young to 0.056 ± 0.03 in old patients. The pressure–strain modulus increased two-fold from 68.4 ± 30.5 kPa in young to 162.0 ± 93.5 kPa in old patients, and the systolic AA wall tension increased from 268.5 ± 31.3 kPa in young to 304.9 ± 49.2 kPa in old patients. The AA dilates and stiffens with aging which increases the vessel wall tension, likely predisposing aneurysm and dissection.
Starting Page	2565
Ending Page	2574
Page Count	10
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	41
Issue Number	12
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2013-07-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ascending aorta Aging Mechanics Imaging Elasticity Biomedicine general Biomedical Engineering Biophysics and Biological Physics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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