NDLI: Computational Modelling of Multi-folded Balloon Delivery Systems for Coronary Artery Stenting: Insights into Patient-Specific Stent Malapposition

Content Provider	Springer Nature Link
Author	Ragkousis, Georgios E. Curzen, Nick Bressloff, Neil W.
Copyright Year	2015
Abstract	Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or “stenting” is not free of complications. Stent malapposition (SM) is a common feature of “stenting” particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an important risk factor for stent thrombosis and recently it has been associated with longitudinal stent deformation. SM is the result of many factors including reference diameter, vessel tapering, the deployment pressure and the eccentric anatomy of the vessel. For the purpose of the present paper, virtual multi-folded balloon models have been developed for simulated deployment in both constant and varying diameter vessels under uniform pressure. The virtual balloons have been compared to available compliance charts to ensure realistic inflation response at nominal pressures. Thereafter, patient-specific simulations of stenting have been conducted aiming to reduce SM. Different scalar indicators, which allow a more global quantitative judgement of the mechanical performance of each delivery system, have been implemented. The results indicate that at constant pressure, the proposed balloon models can increase the minimum stent lumen area and thereby significantly decrease SM.
Starting Page	1786
Ending Page	1802
Page Count	17
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	43
Issue Number	8
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-01-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Coronary stents Balloon delivery systems Patient-specific model Stent malapposition Finite element analysis Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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