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Continuous Left Ventricular Ejection Fraction Monitoring by Aortic Pressure Waveform Analysis

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Continuous Left Ventricular Ejection Fraction Monitoring by Aortic Pressure Waveform Analysis

Content Provider	Springer Nature Link
Author	Swamy, Gokul Kuiper, Jacob Gudur, Madhu S. R. Olivier, N. Bari Mukkamala, Ramakrishna
Copyright Year	2009
Abstract	We developed a technique to monitor left ventricular ejection fraction (EF) by model-based analysis of the aortic pressure waveform. First, the aortic pressure waveform is represented with a lumped parameter circulatory model. Then, the model is fitted to each beat of the waveform to estimate its lumped parameters to within a constant scale factor equal to the arterial compliance (C a). Finally, the proportional parameter estimates are utilized to compute beat-to-beat absolute EF by cancelation of the C a scale factor. In this way, in contrast to conventional imaging, EF may be continuously monitored without any ventricular geometry assumptions. Moreover, with the proportional parameter estimates, relative changes in beat-to-beat left ventricular end-diastolic volume (EDV), cardiac output (CO), and maximum left ventricular elastance (E max) may also be monitored. To evaluate the technique, we measured aortic pressure waveforms, reference EF and EDV via standard echocardiography, and other cardiovascular variables from six dogs during various pharmacological influences and total intravascular volume changes. Our results showed overall EF and calibrated EDV root-mean-squared-errors of 5.6% and 4.1 mL, and reliable estimation of relative E max and beat-to-beat CO changes. These results demonstrate, perhaps for the first time, the feasibility of estimating EF from only a blood pressure waveform.
Starting Page	1055
Ending Page	1068
Page Count	14
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	37
Issue Number	6
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2009-03-24
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Arteries Blood pressure Cardiac output End-diastolic volume Hemodynamics Left ventricle Parameter estimation Pulse contour analysis Variable elastance model Windkessel model Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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Continuous cardiac output monitoring by peripheral blood pressure waveform analysis

Estimation of the Aortic Pressure Waveform and Beat-to-Beat Relative Cardiac Output Changes From Multiple Peripheral Artery Pressure Waveforms

Modeling the Instantaneous Pressure–Volume Relation of the Left Ventricle: A Comparison of Six Models

Clinical Relevance of the LVEDD and LVESD Trajectories in HF Patients With LVEF < 35%

Overcoming the Limits of Ejection Fraction and Ventricular-Arterial Coupling in Heart Failure

Proportional Relations Between Systolic, Diastolic and Mean Pulmonary Artery Pressure are Explained by Vascular Properties

Carotid Reservoir Pressure Decrease After Prolonged Head Down Tilt Bed Rest in Young Healthy Subjects Is Associated With Reduction in Left Ventricular Ejection Time and Diastolic Length

Corrigendum: Carotid reservoir pressure decrease after prolonged head down tilt bed rest in young healthy subjects is associated with reduction in left ventricular ejection time and diastolic length

Cardiac Output and Left Atrial Pressure Monitoring by Right Ventricular Pressure Waveform Analysis for Potential Implantable Device Application

Continuous Left Ventricular Ejection Fraction Monitoring by Aortic Pressure Waveform Analysis

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Continuous cardiac output monitoring by peripheral blood pressure waveform analysis

Estimation of the Aortic Pressure Waveform and Beat-to-Beat Relative Cardiac Output Changes From Multiple Peripheral Artery Pressure Waveforms

Modeling the Instantaneous Pressure–Volume Relation of the Left Ventricle: A Comparison of Six Models

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Cardiac Output and Left Atrial Pressure Monitoring by Right Ventricular Pressure Waveform Analysis for Potential Implantable Device Application

Continuous Left Ventricular Ejection Fraction Monitoring by Aortic Pressure Waveform Analysis