NDLI: Calculation of the Outcomes of Remodeling of Arteries Subjected to Sustained Hypertension Using a 3D Two-Layered Model

Content Provider	Springer Nature Link
Author	Rachev, Alexander Taylor, W. Robert Vito, Raymond P.
Copyright Year	2013
Abstract	Arteries manifest a remodeling response to long-term alterations in arterial pressure and blood flow by changing geometry, structure, and composition through processes driven by perturbations of the local stresses in the vascular wall from their baseline values. The objective of this study is twofold—to develop a general method for calculating the remodeling responses of an artery considered as a two-layered tube; and to provide results for adaptive and maladaptive remodeling of a coronary artery. By formulating an inverse problem of vascular mechanics, the geometrical dimensions and mechanical properties of an artery are calculated from a prescribed deformed configuration, stress field, structural stiffness, and applied load. As an illustrative example we consider a human LAD coronary artery in both a perfect and incomplete adaptive response to a sustained step-wise change in pressure and a maladaptive response due to impaired remodeling of adventitia. The results obtained show that adventitia plays an important role in vascular mechanics when an artery is subjected to high arterial pressure. In addition to its well-known short term function of preventing over-inflation of an artery, it seems reasonable to accept that the manner by which adventitia remodels in response to a chronic increase in pressure is essential for preserving normal arterial function or may lead to an increased risk of developing vascular disorders.
Starting Page	1539
Ending Page	1553
Page Count	15
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	41
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2013-01-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vascular solid mechanics Finite elasticity Adaptive and maladaptive remodeling Coronary artery Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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