NDLI: The Cumulative and Sublethal Effects of Turbulence on Erythrocytes in a Stirred-Tank Model

Content Provider	Springer Nature Link
Author	Aziz, Abdulhameed Werner, Brian C. Epting, Kevin L. Agosti, Christopher D. Curtis, Wayne R.
Copyright Year	2007
Abstract	Mechanical forces generated by prosthetic heart devices (artificial valves, artificial hearts, ventricular assist devices) have been known to cause damage and destruction of erythrocytes. Turbulent flow within such devices generates shear stresses and can induce cell damage. Current models of cell damage rate utilize only the power input per unit mass as a modeling parameter. A stirred-tank reactor provides for a more extensive characterization of turbulence through eddy scale calculations. Through a simplified model, turbulence can be characterized by evaluating the Kolmogorov microscale. Our analysis of erythrocyte rupture in a stirred tank reactor suggests that parameters such as eddy wavelength and eddy velocity may better characterize and model the turbulent damage. Further, hemolysis of red blood cells by turbulent effects has been shown to have a fixed rate for constant levels of power input. Damage inflicted on the remaining, intact erythrocytes (sublethal damage) was evaluated by exposure to turbulence followed by osmotic fragility (OF) testing. Logistic models were fit to the OF data indicating a significant osmotic sensitivity in the sublethal damaged population between control and turbulence-exposed cells (χ2 test; p < 0.001). This susceptibility indicates a significant cell population more susceptible to destruction as a result of turbulent exposure. This work has therefore helped identify optimization parameters for evaluating cell damage potential when engineering cardiovascular prosthetic devices.
Starting Page	2108
Ending Page	2120
Page Count	13
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	35
Issue Number	12
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2007-10-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hemolysis Kolmogorov Eddy Laminar Cardiac Cardiovascular Vascular Prosthetic Valve Red blood cell Blood Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Significance of Extensional Stresses to Red Blood Cell Lysis in a Shearing Flow

Models of Flow-Induced Loading on Blood Cells in Laminar and Turbulent Flow, with Application to Cardiovascular Device Flow

Mechanical valve fluid dynamics hemolysis

Effect of Eddy Length Scale on Mechanical Loading of Blood Cells in Turbulent Flow

Use of Computational Fluid Dynamics to Analyze Blood Flow, Hemolysis and Sublethal Damage to Red Blood Cells in a Bileaflet Artificial Heart Valve

A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model

Two-Dimensional Simulation of Red Blood Cell Deformation and Lateral Migration in Microvessels

Flow-Induced Damage to Blood Cells in Aortic Valve Stenosis

In Vivo Dynamic Deformation of the Mitral Valve Annulus

The Cumulative and Sublethal Effects of Turbulence on Erythrocytes in a Stirred-Tank Model

Similar Documents

Significance of Extensional Stresses to Red Blood Cell Lysis in a Shearing Flow

Models of Flow-Induced Loading on Blood Cells in Laminar and Turbulent Flow, with Application to Cardiovascular Device Flow

Mechanical valve fluid dynamics hemolysis

Effect of Eddy Length Scale on Mechanical Loading of Blood Cells in Turbulent Flow

Use of Computational Fluid Dynamics to Analyze Blood Flow, Hemolysis and Sublethal Damage to Red Blood Cells in a Bileaflet Artificial Heart Valve

A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model

Two-Dimensional Simulation of Red Blood Cell Deformation and Lateral Migration in Microvessels

Flow-Induced Damage to Blood Cells in Aortic Valve Stenosis

In Vivo Dynamic Deformation of the Mitral Valve Annulus

The Cumulative and Sublethal Effects of Turbulence on Erythrocytes in a Stirred-Tank Model