NDLI: Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution

Content Provider	Springer Nature Link
Author	Vorov, Roman S. Stalker, Timothy J. Brass, Lawrence F. Diamond, Scott L.
Copyright Year	2013
Abstract	The mouse laser injury thrombosis model provides up to 0.22 μm-resolved voxel information about the pore architecture of the dense inner core and loose outer shell regions of an in vivo arterial thrombus. Computational studies were conducted on this 3D structure to quantify transport within and around the clot: Lattice Boltzmann method defined vessel hemodynamics, while passive Lagrangian Scalar Tracking with Brownian motion contribution simulated diffusive-convective transport of various inert solutes (released from lumen or the injured wall). For an input average lumen blood velocity of 0.478 cm/s (measured by Doppler velocimetry), a 0.2 mm/s mean flow rate was obtained within the thrombus structure, most of which occurred in the 100-fold more permeable outer shell region (calculated permeability of the inner core was 10−11 cm2). Average wall shear stresses were 80–100 dyne/cm2 (peak values >200 dyne/cm2) on the outer rough surface of the thrombus. Within the thrombus, small molecule tracers (0.1 kDa) experienced ~70,000 collisions/s and penetrated/exited it in about 1 s, whereas proteins (~50 kDa) had ~9000 collisions/s and required about 10 s (tortuosity ~2–2.5). These simulations help define physical processes during thrombosis and constraints for drug delivery to the thrombus.
Starting Page	1297
Ending Page	1307
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	41
Issue Number	6
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2013-02-20
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blood Lattice Boltzmann Confocal microscopy Brownian Diffusion Permeability Stresses Drug delivery Computation Modeling Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution

Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution

A model of fluid, erythrocyte, and solute transport in the lung

Measurement of Solute Transport in the Endothelial Glycocalyx Using Indicator Dilution Techniques

Determination of Critical Parameters in Platelet Margination

Simultaneous Measurement of Anisotropic Solute Diffusivity and Binding Reaction Rates in Biological Tissues by FRAP

Modeling Fluorescence Recovery After Photobleaching in Loaded Bone: Potential Applications in Measuring Fluid and Solute Transport in the Osteocytic Lacunar-Canalicular System

Anisotropic Solute Diffusion Tensor in Porcine TMJ Discs Measured by FRAP with Spatial Fourier Analysis

Anisotropic Diffusive Transport in Annulus Fibrosus: Experimental Determination of the Diffusion Tensor by FRAP Technique

Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution

Similar Documents

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution

Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution

A model of fluid, erythrocyte, and solute transport in the lung

Measurement of Solute Transport in the Endothelial Glycocalyx Using Indicator Dilution Techniques

Determination of Critical Parameters in Platelet Margination

Simultaneous Measurement of Anisotropic Solute Diffusivity and Binding Reaction Rates in Biological Tissues by FRAP

Modeling Fluorescence Recovery After Photobleaching in Loaded Bone: Potential Applications in Measuring Fluid and Solute Transport in the Osteocytic Lacunar-Canalicular System

Anisotropic Solute Diffusion Tensor in Porcine TMJ Discs Measured by FRAP with Spatial Fourier Analysis

Anisotropic Diffusive Transport in Annulus Fibrosus: Experimental Determination of the Diffusion Tensor by FRAP Technique

Simulation of Intrathrombus Fluid and Solute Transport Using In Vivo Clot Structures with Single Platelet Resolution