NDLI: Effect of a growth hormone treatment on bone orthotropic elasticity in dwarf rats

Content Provider	Springer Nature Link
Author	Kohles, Sean S. Martinez, Daniel A. Bowers, James R. Vailas, Arthur C. Vanderby, Ray
Copyright Year	1997
Abstract	A refinement of the current ultrasonic elasticity technique was used to measure the orthotropic elastic properties of rat cortical bone as well as to quantify changes in elastic properties, density, and porosity of the dwarf rat cortex after a treatment with recombinant human growth hormone (rhGH). The ultrasonic elasticity technique was refined via optimized signal management of high-frequency wave propagation through cubic cortical specimens. Twenty dwarf rats (37 days old) were randomly assigned to two groups (10 rats each). The dwarf rat model (5–10% of normal GH) was given subcutaneous injections of either rhGH or saline over a 14-day treatment period. Density was measured using Archimedes’ technique. Porosity and other microstructural characteristics were also explored via scanning electron microscopy and image analysis. Statistical tests verified significant decreases in corticla orthotropic Young’s (−26.7%) and shear (−16.7%) moduli and density (−2.42%) concomitant with an increase in porosity (+125%) after rhGH treatments to the dwarf model (p<0.05). A change in material symmetry from orthotropy toward planar isotropy within the radial-circumferential plane after GH treatments was also noted. These results demonstrate some alteration in bone properties at this time interval. Structural implications of these changes throughout physiological loading regimens should be explored.
Starting Page	77
Ending Page	85
Page Count	9
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	25
Issue Number	1
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	1997-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ultrasonic elasticity Cortical bone Dwarfism Rat model Growth hormone Biomedicine general Biomedical Engineering Biophysics/Biomedical Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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