NDLI: Cellularized Microcarriers as Adhesive Building Blocks for Fabrication of Tubular Tissue Constructs

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Cellularized Microcarriers as Adhesive Building Blocks for Fabrication of Tubular Tissue Constructs

Content Provider	Springer Nature Link
Author	Twal, Waleed O. Klatt, Sandra C. Harikrishnan, Keerthi Gerges, Ebtesam Cooley, Marion A. Trusk, Thomas C. Zhou, Boran Gabr, Mohamed G. Shazly, Tarek Lessner, Susan M. Markwald, Roger R. Argraves, W. Scott
Copyright Year	2013
Abstract	To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose molds and found to adhere to form living tubular tissues. The ability of cellularized microcarriers to adhere to one another involved cellular and extracellular matrix bridging that included the formation of epithelium-like cell layers lining the lumenal and ablumenal surfaces of the constructs and the deposition of collagen and elastin fibers. The tubular tissues behaved as elastic solids, with a uniaxial mechanical response that is qualitatively similar to that of native vascular tissues and consistent with their elastin and collagen composition. Linearized measures of the mechanical response of the fabricated tubular tissues at both low and high strains were observed to increase with duration of static culture, with no significant loss of stiffness following decellularization. The findings highlight the utility of cellularized macroporous gelatin microcarriers as self-adhering building blocks for the fabrication of living tubular structures.
Starting Page	1470
Ending Page	1481
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	42
Issue Number	7
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2013-08-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Macroporous microcarriers Cultispher Tissue engineering Isotropic Elastic Biomaterial Elastin Collagen Endothelial cells Vascular smooth muscle cells Replacement blood vessels Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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